Endocrine Abstracts

Thyroid cancer is the most common endocrine malignancy. However, some aspects of its management remain controversial. The protocols provided by the British, European and American Thyroid Associations have changed recently and continue to evolve.We have audited the management of patients with thyroid cancer in a tertiary referral hospital and compared it with the guidelines from the Consensus Statement published by the European Thyroid Cancer Taskforce in...

It was shown recently that orbital fibroblasts express intensively CD40 and its ligation stimulates proinflammatory cytokines, glicosoaminoglycans and PGE2 production. CD40/CD154 interaction in the pathogenesis of Graves’ orbitopathy (GO) is suggested an important pathway of T cells induced fibroblast activation and proliferation.Aim: To assess the role of CD40/CD154 interaction in GO pathogenesis and to estimate usefulness of soluble CD4...

Iatrogenic Cushing syndrome caused by the use of steroid medications is common because of the widespread use of these medications for the treatment of many diseases, however development of Cushing syndrome from the topical corticosteroids is very rare in adults.A 45-year-old men (BMI: 44 kg/m2), with a history of psoriasis, developed manifestations of Cushing syndrome, which included weight gain, central obesity, moon face, facial plethora, bu...

The first degree relatives of patients with diabetes type 1 have increased genetic risk of developing clinical disease. In the population of Polish diabetic subjects the most frequent alleles are HLA- DRB1*04, DRB1*03, DQA1 and DQB1. The ‘high-risk genotype’ may differ among populations.The aim of this paper was to analyze prevalence of genetic risk factors in patients with new-onset diabetes in Lower Silesia and to compare the data with Polish...

Results of many studies indicate that the BsmI polymorphism in the vitamin D receptor (VDR) gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of osteoporosis. As far as long-term glucocorticoid treatment is a major risk factor for osteoporosis development, we looked for the BsmI VDR gene polymorphism and its relation to phenotypic features characterizing bone status (BMD and metabolic bone turnover) in 74 premenopausal women: 5...

Background: Thyroid hemiagenesis (TH) is a rare inborn anomaly, occurring if one of the thyroid lobes fails to develop. Due to mostly asymptomatic course, it is usually detected incidentally, during investigation of concomitant abnormalities of the thyroid function or structure.Case report: A case of Graves’ hyperthyroidism following primary hypothyroidism due to Hashimoto’s thyroiditis (HT), accompanying a TH, is reported. The patient first pr...

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age characterized by chronic anovulation and hyperandrogenism, and also associated with insulin resistance. Subclinical chronic inflammation might be an important pathogenetic factor in the development of insulin resistance, type 2 diabetes and recently has been also observed in PCOS. There is evidence for a familial predisposition not only to hormonal abnormalities but also to metabolic d...

Tumor angiogenesis is believed to result from an imbalance of pro- and anti-angiogenic factors. Angiogenesis is an important component in the development of thyroid goitre. Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) represents a family of specific endothelial cell mitogens involved in normal angiogenesis and in tumor development. Consequently, a panel of anti-angiogenic factors was addressed in a representative sample of VEGF receptor-2 (VEGFR-...

Type 1 deiodinase (D1) catalyses deiodination of tyroxine (T4), which leads either to synthesis of triiodothyronine or reverse triiodothyronine (rT3). T3 can influence the process of neoplasia through its receptors which act as transcription factors and regulate the expression of many tumor suppressor genes and oncogenes. The aim of the study was to analyze the changes in expression of alternatively spliced variants of D1 mRNA in clear cell Renal Cell Carcinoma (ccRCC), which ...

Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are weak adrenal androgens, which may exert anabolic effect on bone tissue.We have measured serum DHEAS levels and bone mineral density in lumbar spine and femoral neck in 131 healthy, agile, postmenopausal women aged 59–89. There were no diseases which aggravate bone loss and no hormonal replacement therapy in medical history of participants.Women were divided into groups...